2021年南通大學(xué)醫(yī)學(xué)院醫(yī)學(xué)生物化學(xué)與分子生物學(xué)調(diào)劑信息

2025考研復(fù)試標(biāo)準(zhǔn)班

2025考研復(fù)試特訓(xùn)班【1v1個(gè)性批改+模擬面試+聽口糾音】

 一、課題組介紹

秘曉林，博士，教授，博士研究生導(dǎo)師。入選中國(guó)科學(xué)院“引進(jìn)國(guó)外杰出人才--百人計(jì)劃”、遼寧省“攀登學(xué)者”。國(guó)家自然科學(xué)基金、國(guó)家重大科學(xué)研究計(jì)劃、博士后科學(xué)基金、美國(guó)國(guó)家科學(xué)基金研究生項(xiàng)目等評(píng)議人，sci雜志international journal of
nanomedicine顧問編委，current proteomics、plos one編委，中國(guó)生化藥物雜志編委，中國(guó)環(huán)境誘變劑學(xué)會(huì)理事，遼寧省醫(yī)學(xué)會(huì)醫(yī)學(xué)遺傳學(xué)分會(huì)副主任委員，biomaterials、genetics、international journal of nanomedicine等sci雜志審稿人。主持國(guó)家重點(diǎn)基礎(chǔ)研
究計(jì)劃“973”課題、國(guó)家自然科學(xué)基金項(xiàng)目、中國(guó)科學(xué)院創(chuàng)新項(xiàng)目等。

1990年畢業(yè)于蘭州大學(xué)生物化學(xué)專業(yè)，獲學(xué)士學(xué)位；1996年畢業(yè)于衛(wèi)生部蘭州生物制品研究所免疫學(xué)和微生物學(xué)專業(yè)，獲碩士學(xué)位；1999年畢業(yè)于中國(guó)預(yù)防醫(yī)學(xué)科學(xué)院病原生物學(xué)專業(yè)，獲博士學(xué)位。同年赴美國(guó)，在國(guó)立衛(wèi)生研究院（national institutes of health）國(guó)
家癌癥研究所（national cancer institute）從事博士后研究，隨后任職美國(guó)國(guó)立衛(wèi)生研究院國(guó)家癌癥研究所研究學(xué)者。作為通訊作者，研究成果發(fā)表在proceedings of national academy of sciences usa、plos genetics、oncogene、biomaterials、human
molecular genetics等國(guó)際知名學(xué)術(shù)期刊。

研究方向

1.非編碼RNA應(yīng)答DNA損傷，調(diào)節(jié)細(xì)胞周期、凋亡、轉(zhuǎn)錄的功能和機(jī)制；

2.腸道干細(xì)胞再生與分化的表觀遺傳調(diào)控。

代表性文章（*通訊作者）

1.dai z., li d. *, du x., ge y., hursh d.a., bi x. * drosophila caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes. plos genetics. 2020. 16(10):e1009140.  if 5.4

2.li d., liu y., pei c., zhang p., pan l., xiao j., meng s., yuan z., bi x. * mir-285-yki/mask double-negative feedback loop mediates blood-brain barrier integrity in drosophila. proceedings of national academy of sciences usa. 2017. 114(12): e2365-e2374.  if 9.7

3.song f., li d. *, wang y., bi x.* drosophila caliban mediates g1-s transition and ionizing radiation induced s phase checkpoint. cell cycle. 2018. 17(18): 2256-2267.  if 3.3

4.yuan q., tian r., zhao h., li l., bi x. * multiple arginine residues are methylated in drosophila mre11 and required for survival following ionizing radiation. g3: genes genomes genetics. 2018. 8 (6): 2099-2106.  if 2.7

5.li d. and bi x. * effect of teratogens on development of drosophila melanogaster. teratogenicity testing: methods and protocols. methods in molecular biology. springer. 2018. 1797:233-241.

6.cong, w., wang, p., qu, y., tang, j., bai, r., zhao, y., chen, c. *, bi, x. * evalutation of the influence of fullerenol on aging and stress resistance using caenorhabditis elegans. biomaterials. 2015. 42:78-86.  if 8.6

7.jiang k., liu m., lin g., mao b., cheng w., liu h., gal j., zhu h., yuan z., deng w., liu q., gong p., bi x. *, meng s. * tumor suppressor spred2 interaction with lc3 promotes autophagosome maturation and induces autophagy-dependent
cell death. oncotarget. 2016. 7 (18): 25652-25667.  if 5.2

8.chen, h., wang, b., feng, w. *, du, w., ouyang, h., chai, z., bi, x.*  oral magnetite nanoparticles disturb the development of drosophila melanogaster from oogenesis to adult emergence. nanotoxicology. 2015. 9(3):302-312.  if 7.9

9.yuan, q., han, j., cong, w., ge, y., ma, d., dai, z., li, y. *, bi, x. * docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced
myelosuppression toxicity. international journal of nanomedicine. 2014.  9(1): 4829-4846.  if 4.3

10.fang, g., zhang, d., yin, h., zheng, l., bi, x.*, yuan, l.*  centlein maintains centrosome cohesion by bridging an interaction between c-nap1 and cep68. journal of cell science. 2014.  127 :1631-1639.  if 5.4

11.wang, y., wang, z., joshi, bh., puri, r., stultz, b., yuan, q., bai, y., zhou, p., yuan, z., hursh, da., bi, x.* the tumor suppressor caliban regulates dna damage induced apoptosis through p53-dependent and ╟independent activity.
oncogene. 2013. 32(33):3857-66.  if 8.6

12.liu, w., jiang, f., bi, x.*, zhang, q*. drosophila fmrp participates in dna damage response by regulating g2/m cell cycle checkpoint and apoptosis. human molecular genetics. 2012, 21(21):4655-68.  if 7.7

13.kong, l., yuan y., zhu, h., li, y., guo, q., zhao, y., wang, q., bi, x.*, gao,x*. the suppression of prostate lncap cancer cells growth by selenium nanoparticles through akt/mdm2/ar controlled apoptosis. biomaterials. 2011.32(27)：
6515-6522.  if 7.6

14.wang, p., bai, y., song, b., wang, y., liu, d., lai, y., bi, x.*, yuan, z*. pp1a-mediated dephosphorylation positively regulates yap2 activity. plos one. 2011.6(9):e24288.  if 4.1

15.gao, g., bi, x., chen, j., srikanta, d., rong, ys. mre11-rad50-nbs complex is required to cap telomeres during drosophila embryogenesis. proceedings of national academy of sciences usa. 2009. 106(26): 10728╟10733.(equal
contribution).  if 9.4

16.bi, x., jones, t., abbasi, f., lee, h., stultz, b., hursh, d., mortin, m. drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. oncogene. 2005. 24:8229-8239.  if 6.8

17.bi, x., srikanta, d., fanti,l., pimpinelli,s., badugu,r., kellum,r., rong, y.s. * drosophila atm and atr checkpoint kinases control partially redundant pathways for telomere maintenance. proceedings of national academy of sciences
usa. 2005. 102(42):15167-15172.  if 10.2

18.bi, x., gong, m., srikanta, d., rong, y.s. * drophila atm and mre11 are essential for the g2/m checkpoint induced by low-dose irradiation. genetics. 2005. 171:845-847.  if 4.4

19.bi, x., wei, s.d., rong, y.s. * telomere protection without a telomerase: the role of atm and mre11 in drosophila telomere maintenance. current biology. 2004. 14:1348-1353.  if 11.9

20.bi, x., kajava, a., demidenko, z., jones, t., mortin, m. * the carboxyl terminus of prospero regulates its subcellular localization.  molecular and cellular  biology.  2003. 23 (3): 1014-1024.  if 8.9

二、招收條件和招生專業(yè)

符合我校2021年攻讀碩士學(xué)位研究生招生簡(jiǎn)章要求，初試成績(jī)達(dá)到全國(guó)一類地區(qū)碩士研究生初試分?jǐn)?shù)線的普通全日制本科考生。要求生命科學(xué)背景，對(duì)科研有濃厚興趣，勤于思考，能夠閱讀英語(yǔ)專業(yè)文獻(xiàn)，具備團(tuán)隊(duì)精神。

招生院系：醫(yī)學(xué)院。

招生專業(yè)：醫(yī)學(xué)生物化學(xué)與分子生物學(xué)  1001z2。

有攻讀博士意向的考生優(yōu)先考慮。

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